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Journal Article 1

Year

2014 1

Keywords

human lactoferrin bacterial artificial chromosome (hLF BAC) 1

milk 1

recombinant human butyrylcholinesterase (rhBCHE) 1

transgenic mice 1

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Expression of recombinant human butyrylcholinesterase in the milk of transgenic mice

Dan LU,Shengzhe SHANG,Shen LIU,Ying WU,Fangfang WU,Tan TAN,Qiuyan LI,Yunping DAI,Xiaoxiang HU,Yaofeng ZHAO,Ning LI

Frontiers of Agricultural Science and Engineering 2014, Volume 1, Issue 3,   Pages 179-184 doi: 10.15302/J-FASE-2014020

Abstract: Butyrylcholinesterase (BCHE) is a natural bioscavenger that protects humans against organophosphate toxicityExpression analysis showed that recombinant hBCHE (rhBCHE) was expressed efficiently in the mammary glandof the transgenic mice and the concentration of rhBCHE in the milk of individual mice ranged from 76Protein function tests showed that rhBCHE has the same enzymatic activity as the native hBCHE.Our results pave the way for making transgenic livestock to produce large quantities of rhBCHE.

Keywords： recombinant human butyrylcholinesterase (rhBCHE)     human lactoferrin bacterial artificial chromosome (hLF    

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Expression of recombinant human butyrylcholinesterase in the milk of transgenic mice

Dan LU,Shengzhe SHANG,Shen LIU,Ying WU,Fangfang WU,Tan TAN,Qiuyan LI,Yunping DAI,Xiaoxiang HU,Yaofeng ZHAO,Ning LI

Journal Article